However, it soon became clear that heroin was rapidly metabolised to morphine and consequently shared all of its associated risks, including addiction, central nervous system depression, and death. In the early part of the 20th century, the morbidity associated with opioids led many countries to pass laws restricting their use. For example, the United States approved the Harrison Narcotics Tax Act in 1914, making it illegal for physicians to prescribe opioids to treat addiction, and the League of Nations banned heroin outright in 1925.
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